Donald Chimalilo and Adam Gell come into the starting XI in place of Aaron Haswell and Michael Woods.
Chimalilo is the Seasiders' top scorer so far this season and provides support for Jake Charles and Layton Watts in attack against his former club.
Goalkeeper Shane Bland matches Paul Pitman's club record of 484 appearances for the club as he starts between the posts.
Skipper Lewis Hawkins has recovered sufficiently from injury to take his place on the bench as the Seasiders look to build on their recent run of going unbeaten in five of their last six league outings.
Whitby Town: Shane Bland (c), Connor Smith, Sam Collins, Gary Liddle, Alex Nelson, Donald Chimalilo, Harley Dawson, Jake Charles, Layton Watts, James Harrison
Substitutes: Nathan McGinley, Aaron Haswell, Lewis Hawkins, Jarrett Rivers, Matthew Tymon